
Beyond symptom relief, a breakthrough device designed to treat the underlying cause of COPD with Chronic Bronchitis
Who qualifies for our clinical trial?


Beyond symptom relief, a breakthrough device designed to treat the underlying cause of COPD with Chronic Bronchitis
Introduction to RejuvenAir®
The RejuvenAir System is a revolutionary cryosurgical device which applies a precise thermal dose or “metered cryospray” of extremely cold, -196°C liquid nitrogen to targeted areas within the lungs through a minimally invasive, often outpatient or same-day bronchoscopic procedure.
CAUTION: Investigational device. Limited by Federal law to investigational use.
About COPD with Chronic Bronchitis
Chronic Bronchitis is the largest disease subset of Chronic Obstructive Pulmonary Disease (COPD).
Unlike common Bronchitis, which is acute and clears up quickly, Chronic Bronchitis (CB) is characterized by a long-term productive cough, breathlessness and/or wheezing as well as a tight chest sensation.
The persistent cough itself can be debilitating. Patients with Chronic Bronchitis often avoid social situations and give up activities, further contributing to a decline in overall well-being and quality of life. While current medications help alleviate symptoms, they don’t address the underlying cause of the disease and are largely ineffective.
How Metered Cryospray Works
The RejuvenAir System delivers small, metered doses of cryogen spray which flash freeze the surface area of damaged airways. Diseased cells are destroyed, leaving behind the extra-cellular structure that allows for new healthy cells, including cilia and mucus-producing goblet cells, to repopulate.
RejuvenAir rejuvenates the airways.
How Metered Cryospray Works




-196° C flash freeze causes instant cell death


Preservation of extracellular matrix (ECM)


Intact ECM enables healing with limited scarring and fibrosis
The RejuvenAir System delivers small, metered doses of cryogen spray which flash freeze the surface area of damaged airways. Diseased cells are destroyed, leaving behind the extra-cellular structure that allows for new healthy cells, including cilia and mucus-producing goblet cells, to repopulate.
RejuvenAir rejuvenates the airways.
The SPRAY-CB Clinical Trial
Researching a NEW option for people living with Chronic Bronchitis
The RejuvenAir System Trial for COPD with Chronic Bronchitis (SPRAY-CB) is currently recruiting patients in the United States. This trial is designed to continue to explore the safety and effectiveness of metered cryospray treatments in patients suffering from Chronic Bronchitis.
Participation in the SPRAY-CB Trial
If you are wondering whether you or somebody you know might qualify to participate in this trial, we invite you to answer a short questionnaire; after which, we will let you know whether you might be a suitable candidate.
For more information, refer to the ClinicalTrials.gov website. Details are available for the United States SPRAY-CB Study and a smaller European Study.
The RejuvenAir System is CE marked in the European Union and limited to investigational use in the United States and is currently not for sale.
Find out if you qualify
To proceed, select the participating study center nearest to you on the map. You will be taken to the www.spray-cb.com website. Here you can watch an educational video, complete a short questionnaire and, if qualified, register your details.
Title | Address | Description |
---|---|---|
Temple University | 1801 N Broad St, Philadelphia, PA 19122, USA | ENROLLING |
UC Davis Medical Center | 2279 45th St, Sacramento, CA 95817, USA | ENROLLING |
NYU Langone Medical Center | 550 1st Avenue, New York, NY 10016, USA | ENROLLING |
UT Southwestern Medical Center | 5939 Harry Hines Blvd, Dallas, TX 75390, USA | ENROLLING |
El Camino Hospital | 701 E El Camino Real, Mountain View, CA 94040, USA | ENROLLING |
Beth Israel Deaconess Medical Center | 185 Pilgrim Rd, Boston, MA 02215, USA | ENROLLING |
Sarasota Memorial Hospital | 1700 S Tamiami Trail, Sarasota, FL 34239, USA | ENROLLING |
Medical University of South Carolina | 96 Jonathan Lucas St, Charleston, SC 29425, USA | ENROLLING |
Duke University School of Medicine | Durham, NC, USA | ENROLLING |
Advanced Pulmonary Research Institute | 13005 Southern Blvd, Loxahatchee, FL 33470, USA | ENROLLING |
Henry Ford Hospital | 2799 W Grand Blvd, Detroit, MI 48202, USA | NOT YET ENROLLING |
The Cleveland Clinic Foundation | 9500 Euclid Ave, Cleveland, OH 44106, USA | NOT YET ENROLLING |
University Of Wisconsin Hospital | Highland Ave, Madison, WI, USA | NOT YET ENROLLING |
Louisiana State University Medical Center | Shreveport, LA 71103, USA | NOT YET ENROLLING |
Ohio State University | Davis Heart and Lung Research Institute, 473 W 12th Ave, Columbus, OH 43210, USA | ENROLLING |
Spectrum Health | 4100 Lake Dr SE, Grand Rapids, MI 49546, USA | NOT YET ENROLLING |
Johns Hopkins Hospital | 600 N Wolfe St, Baltimore, MD 21287, USA | ENROLLING |


Find out if you qualify
To proceed, select the study center nearest to you from the list below . You will be taken to the www.spray-cb.com website. Here you can watch educational videos, complete a short questionnaire and, if qualified, register your details.
About Us
CSA Medical is currently conducting clinical studies with the RejuvenAir System. The clinical study aims to evaluate the effectiveness of the RejuvenAir System to reduce mucous production, cough, and inflammation in the Chronic Bronchitis patient population and to determine the extent of improvement in their overall health and quality of life.
News & Resources
CSA Medical Announces Metered Cryospray with the RejuvenAir® System for the treatment of Chronic Bronchitis Featured at the 21st World Congress of Bronchology and Interventional Pulmonology
The RejuvenAir System is designed to address the underlying cause of COPD with Chronic Bronchitis and enable rejuvenative healing of the airways BOSTON, Nov. 23, 2020 -- CSA Medical, Inc., today announced metered cryospray utilizing the RejuvenAir® System for the...
CSA Medical Announces Enrollment Milestone in a Mechanism of Action Study utilizing the RejuvenAir® System for COPD Patients with Chronic Bronchitis
This study will provide a scientific rationale for the remodeling response and clinical improvements identified in the feasibility study Boston, MA –November 11, 2020: CSA Medical, Inc., today announced that over half of the subjects in a 32 patient study,...
CSA Medical Announces First Procedure in the SPRAY-CB Pivotal Trial for the Treatment of Chronic Bronchitis
The SPRAY-CB trial marks the first pivotal study of a medical device therapy targeting the underlying cause of Chronic Bronchitis. Boston,MA. – October 22, 2020: CSA Medical Inc., a developer of medical devices advancing the power of liquid nitrogen spray cryotherapy,...



131 Hartwell Avenue
Lexington
Massachusetts 02421
CAUTION: Investigational device. Limited by Federal law to investigational use.