
Beyond symptom relief, a breakthrough device designed to treat the underlying cause of COPD with Chronic Bronchitis
Who qualifies for our clinical trial?
Beyond symptom relief, a breakthrough device designed to treat the underlying cause of COPD with Chronic Bronchitis
Introduction to RejuvenAir®
The RejuvenAir System is a revolutionary cryosurgical device which applies a precise thermal dose or “metered cryospray” of extremely cold, -196°C liquid nitrogen to targeted areas within the lungs through a minimally invasive, often outpatient or same-day bronchoscopic procedure.
CAUTION: Investigational device. Limited by Federal law to investigational use.
About COPD with Chronic Bronchitis
Chronic Bronchitis is the largest disease subset of Chronic Obstructive Pulmonary Disease (COPD).
Unlike common Bronchitis, which is acute and clears up quickly, Chronic Bronchitis (CB) is characterized by a long-term productive cough, breathlessness and/or wheezing as well as a tight chest sensation.
The persistent cough itself can be debilitating. Patients with Chronic Bronchitis often avoid social situations and give up activities, further contributing to a decline in overall well-being and quality of life. While current medications help alleviate symptoms, they don’t address the underlying cause of the disease and are largely ineffective.
How Metered Cryospray Works
The RejuvenAir System delivers small, metered doses of cryogen spray which flash freeze the surface area of damaged airways. Diseased cells are destroyed, leaving behind the extra-cellular structure that allows for new healthy cells, including cilia and mucus-producing goblet cells, to repopulate.
RejuvenAir rejuvenates the airways.
How Metered Cryospray Works


-196° C flash freeze causes instant cell death

Preservation of extracellular matrix (ECM)

Intact ECM enables healing with limited scarring and fibrosis
The RejuvenAir System delivers small, metered doses of cryogen spray which flash freeze the surface area of damaged airways. Diseased cells are destroyed, leaving behind the extra-cellular structure that allows for new healthy cells, including cilia and mucus-producing goblet cells, to repopulate.
RejuvenAir rejuvenates the airways.
The SPRAY-CB Clinical Trial
Researching a NEW option for people living with Chronic Bronchitis
The RejuvenAir System Trial for COPD with Chronic Bronchitis (SPRAY-CB) is currently recruiting patients in the United States. This trial is designed to continue to explore the safety and effectiveness of metered cryospray treatments in patients suffering from Chronic Bronchitis.
Find out more about the SPRAY-CB Trial
To find out if you or somebody you know might qualify, watch the video then answer the short questionnaire below and register to continue the process.
Watch the video
Find out if you qualify:
Where the study is enrolling
The map below shows the study centers that are enrolling. For more information, refer to the ClinicalTrials.gov website.
Details are available for the United States SPRAY-CB Study and a smaller European Study.
The RejuvenAir System is CE marked in the European Union and limited to investigational use in the United States and is currently not for sale.
Title | Address | Description |
---|---|---|
Temple University, Philadelphia | 1801 N Broad St, Philadelphia, PA 19122, USA | ENROLLING |
UC Davis Medical Center, Sacramento | 2279 45th St, Sacramento, CA 95817, USA | ENROLLING |
UT Southwestern Medical Center, Dallas | 5939 Harry Hines Blvd, Dallas, TX 75390, USA | ENROLLING |
El Camino Hospital, Mountain View | 701 E El Camino Real, Mountain View, CA 94040, USA | ENROLLING |
Beth Israel Deaconess Medical Center, Boston | 185 Pilgrim Rd, Boston, MA 02215, USA | ENROLLING |
Sarasota Memorial Hospital, Sarasota | 1700 S Tamiami Trail, Sarasota, FL 34239, USA | ENROLLING |
Medical University of South Carolina, Charleston | 96 Jonathan Lucas St, Charleston, SC 29425, USA | ENROLLING |
Duke University School of Medicine, Durham | Durham, NC, USA | ENROLLING |
Advanced Pulmonary Research Institute, Loxahatchee | 13005 Southern Blvd, Loxahatchee, FL 33470, USA | ENROLLING |
Cooper Health | New Brunswick, NJ, USA | ENROLLING |
The Cleveland Clinic Foundation, Cleveland | 9500 Euclid Ave, Cleveland, OH 44106, USA | ENROLLING |
University Of Wisconsin Hospital, Madison | Highland Ave, Madison, WI, USA | ENROLLING |
Louisiana State University Medical Center, Shreveport | Shreveport, LA 71103, USA | ENROLLING |
University of Cincinnati, Cincinnati | Lindner Hall, 2925 Campus Green Dr, Cincinnati, OH 45221, USA | ENROLLING |
St. David's Medical Center, Austin | 1015 E 32nd St, Austin, TX 78705, USA | ENROLLING |
University of Maryland, Baltimore | Um Professional Bldg, 419 W Redwood St, Baltimore, MD 21201, USA | ENROLLING |
Clinical Research Associates of Central PA | 100 Hospital Ave, DuBois, PA 15801, USA | ENROLLING |
Dartmouth-Hitchcock Medical Center, Lebanon | 1 Medical Center Dr, Lebanon, NH 03766, USA | ENROLLING |
Prisma Health-Midlands, Columbia | Columbia, SC, USA | ENROLLING |
Ohio State University, Columbus | Davis Heart and Lung Research Institute, 473 W 12th Ave, Columbus, OH 43210, USA | ENROLLING |
Spectrum Health, Grand Rapids | 4100 Lake Dr SE, Grand Rapids, MI 49546, USA | ENROLLING |
HonorHealth, Scottsdale | Scottsdale, AZ, USA | NOW ENROLLING |
Northwestern University | Rebecca Crown Center, 633 Clark St, Evanston, IL 60208, USA | NOT YET ENROLLING |
Medical College of Wisconsin | 8701 W Watertown Plank Rd, Wauwatosa, WI 53226, USA | NOT YET ENROLLING |

About Us
CSA Medical is currently conducting clinical studies with the RejuvenAir System. The clinical study aims to evaluate the effectiveness of the RejuvenAir System to reduce mucous production, cough, and inflammation in the Chronic Bronchitis patient population and to determine the extent of improvement in their overall health and quality of life.
News & Resources
First Randomized Controlled Study with RejuvenAir® for Chronic Bronchitis shows Clinically Significant Results
Metered Cryospray treats damaged airways enabling a rejuvenative healing response BOSTON, Sept. 6, 2022 /PRNewswire/ -- CSA Medical, Inc., today announced results from the first randomized, controlled study of Metered Cryospray (MCS) utilizing the RejuvenAir®...
CSA Medical Announces Completion of Enrollment in Mechanism of Action Study utilizing the RejuvenAir® System for COPD Patients with Chronic Bronchitis
These results should provide the scientific proof behind the remodeling response and clinical improvements identified in earlier studies Boston, MA—May 12, 2021: CSA Medical, Inc., today announced ® that all subjects have been enrolled in the RejuvenAir System study...
CSA Medical, Inc. Announces Cooper University Health Care is the 20th Clinical Site to Join the SPRAY-CB Pivotal Study for the treatment of Chronic Bronchitis
Boston, MA –April 19, 2021: CSA Medical, Inc., today announced that Wissam Abouzgheib, MD, chief of pulmonary medicine at Cooper University Health Care, Camden, New Jersey, has joined the SPRAY-CB Study investigating a new device treatment for COPD with Chronic...